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The results of this trial are summarized in Table 7: Table 7: Emetic Episodes: Treatment Response in Patients Receiving Moderately Emetogenic Chemotherapy next (Cyclophosphamide-based Regimen Containing Doxorubicin) where to buy zofran Zofran (n 33) Placebo (n 34) P Value Treatment response. Ondansetron: New and troubling data. These higher plasma concentrations may in part be explained by differences in body weight between men and women. IV Preparation, no dilution necessary for premixed injection. Retreatment In single-arm trials, 148 patients receiving cyclophosphamidebased chemotherapy were retreated with Zofran 8 mg three times daily during subsequent chemotherapy for a total of 396 retreatment courses. The FDA said in its Drug Safety Communication that it was working with the manufacturers of all 32 mg dose ondansetron injectable products (brand and generic) to recall them from the market. Originally used for nausea after and operation or chemotherapy, ondansetron is now much more widely used. Skin Urticaria, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Moderately Emetogenic Chemotherapy A randomized, placebo-controlled, doubleblind trial was conducted in the US in 67 patients receiving a cyclophosphamidebased chemotherapy regimen containing doxorubicin. Other (less than 2 Anaphylaxis, bronchospasm, tachycardia, angina, hypokalemia, electrocardiographic alterations, zofran vascular occlusive events, and grand mal seizures. If experienced severely or for a prolonged amount of time, a doctor should be consulted: headache diarrhea constipation weakness tiredness dizziness, the following are more serious side effects. Are with medications not labeled for use in pregnancy, not indicated for nausea and vomiting in pregnancy, and not classified as safe in pregnancy by the Food and Drug Administration. Drug Interaction Studies CYP 3A4 Inducers: Ondansetron elimination may be affected by cytochrome P-450 inducers. Chemotherapy-induced nausea and vomiting: Dilute IV injection (2 mg/mL vials, not premixed injection) in 50 mL D5W. Many mothers rely on anti-nausea drugs to get them through the first few weeks. Daily Fractionated Radiotherapy In an active-controlled, doubleblind trial in 135 patients receiving a 1- to 4- week course of fractionated radiotherapy (180 cGy doses) over a field size of greater than or equal to 100 cm2 to the abdomen, Zofran was significantly more effective. Storage, store at room temperature or refrigerate. Chemotherapy Carmustine, etoposide, and cisplatin zofran do not affect the pharmacokinetics of ondansetron. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation.

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